Author: Walter E. Stumpf
Edition:
Publisher: International Institute of Drug Distribution, Cytopharmacology and Cytotoxicology
Binding: Hardcover
ISBN: 0974051500
Drug Localization in Tissues and Cells
Medical books Drug Localization in Tissues and Cells. Medical books Phosphodiesterase Methods and Protocols. Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonstrate not only the potential role of targeted PDEs, but also their use in further studies of the central role of PDE regulation in intracellular signaling control. These techniques offer clinicians a way to find new therapies for numerous pathologies whose molecular origins are unknown and whose treatment is symptomatic. Alterations of intracellular signaling related to PDE deregulation in such pathologies as inflammation, neurodegeneration, and cancer may explain the difficulties observed in their prevention and treatment. isbn13: 9781588293145
Download link for Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control
Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonst
Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses Presented in step by step detail these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells as well as their visualization in a spatio temporal manner the localization and characterization of their activities in tissues and living cells and the assessment of targeted PDEs in creating specific tools and drugs Additional chapters discuss the generation of PDE4 knockout mice to demonstrate n
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers.
This volume provides an overview of three of these endothelial adhesion
This volume provides an overview of three of these endothelial adhesion
"This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinica
Medical Book Drug Localization in Tissues and Cells
