Ion Channels and Their Inhibitors

Author:
Edition: 2011
Publisher: Springer
Binding: Hardcover
ISBN: 3642199216

Ion Channels and Their Inhibitors

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Medical books Ion Channels and Their Inhibitors. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors Medical books Ion Channels And Their Inhibitors .... Ion Channels And Their Inhibitors SPVMD 9783642199219 09783642199219

Download link for Ion Channels and Their Inhibitors, 9783642199219

Ion Channels And Their Inhibitors SPVMD 9783642199219 09783642199219

Store Search search Title, ISBN and Author Ion Channels and Their Inhibitors by Satya Prakash Gupta Estimated delivery 3-12 business days Format Hardcover Condition Brand New Ion Channels and Their Inhibitors covers recent advances in the structure and functions of ion channels and their inhibitors. Topics include sodium Ion, potassium Ion, chloride Ion, calcium Ion channel inhibitors. Publisher Description Being the crucial components of living cells, ion channels are important targets of ther

Electronics Cameras Computers Software Housewares Sports DVDs Music Books Games Toys in titles descriptions Company Info |Checkout Info |Shipping Info |Return Policy |FAQ's Add us as a favorite seller By continuing with your purchase using the eBay Buy It Now button, you agree to the Buy Terms of Use at http://stores.ebay.com/Buys-Internet-Superstore/Terms.html . Ion Channels And Their Inhibitors - Gupta, Satya Prakash (EDT)THIS IS A BRAND NEW UNOPENED ITEM. Buy SKU: 221715409 If you want addit

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important re

Medical Book Ion Channels and Their Inhibitors

Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

TRP Channels pdf

Author:
Edition: 1
Publisher: CRC Press
Binding: Hardcover
ISBN: 1439818606

TRP Channels (Methods in Signal Transduction Series)

The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. Medical books TRP Channels . However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task Medical books Mammalian Trp Channels As Molecular Targets. Somerset New Jersey USA: John Wiley & Sons Inc 2004. 286 pages. New in publishers shrinkwrap. Hard Cover - Pictorial Cover. New. 8vo - over 7¾" - 9¾" tall.

Download link for Mammalian TRP Channels as Molecular Targets (Novartis Foundation Symposium 258)

Somerset New Jersey USA: John Wiley & Sons Inc 2004. 286 pages. New in publishers shrinkwrap. Hard Cover - Pictorial Cover. New. 8vo - over 7¾" - 9¾" tall.

New Hardcover.

"This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.File Size: 4105 KBPrint Length: 287 pagesPage Numbers Source ISBN: 0470862548Publisher: Wi

format hardback language english publication year 14 04 2011 series methods in signal transduction series subject mathematics sciences subject 2 life sciences general title trp channels author xi zhu michael editor publisher crc pr i llc publication date apr 14 2011 pages 499 binding mixed media product edition 1 st dimensions 6 00 wx 9 00 hx 1 25 d isbn 1439818606 subject medical pharmacology description transient receptor potential trp channels have gained a lot of popularity in recent years

Medical Book TRP Channels

However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task.

A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include

• Mammalian, Drosophila and C. elegans TRP channels
• Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels
• ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation
• Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries
• TRP channel functions in native cells, including smooth muscles, neurons, and cancers

Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.

Connexin Cell Communication Channels

Author:
Edition: 1
Publisher: CRC Press
Binding: Hardcover
ISBN: 1439862575

Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks—connexins—have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Medical books Connexin Cell Communication Channels. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field.

The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological characteristics and examines how they participate in the evolution, organization, function, and regulation of leukocytes, as well as their interaction with other tissues.

The next section examines immunologically related disease scenarios where gap junctions and connexins have been shown to play a fundamental role Medical books Connexin Cell Communication Channels: Roles In The Immune System And Immunopathology. New Hardcover.

Download link for Connexin Cell Communication Channels: Roles In The Immune System And Immunop

New Hardcover.

Contributors: Ernesto Oviedo-Orta - Editor. Format: Hardcover

Medical Book Connexin Cell Communication Channels

Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field.

The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological characteristics and examines how they participate in the evolution, organization, function, and regulation of leukocytes, as well as their interaction with other tissues.

The next section examines immunologically related disease scenarios where gap junctions and connexins have been shown to play a fundamental role. The contributors explain how gap junctional communication participates in the establishment and maintenance of immunological properties such as antibody and cytokine production, as well as lymphocyte immune surveillance in both physiological and pathological conditions. The book explores the most important technical approaches used and how they have been specially adapted to answer key biological questions particular to the mobile nature of leukocytes. It also describes the most recent understanding of how gap junctions and connexins participate in antigen recognition, cross-presentation, lymphocyte activation, and in the assembly and function of the immunological synapse.

Finally, the book focuses on the latest progress made on translating the knowledge gained to specific treatment modalities. Topics in this section include approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system, and enhancing epithelial tissue repair. A comprehensive view of achievements in this promising field, the book will inform and update specialists, clinical practitioners, and those studying the potential for commercial applications.

Barriers and Channels Formed by Tight Junction Proteins I

Author:
Edition: 1
Publisher: Wiley-Blackwell
Binding: Paperback
ISBN: 1573318736

Barriers and Channels Formed by Tight Junction Proteins I (Annals of the New York Academy of Sciences)

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. Medical books Barriers and Channels Formed by Tight Junction Proteins I . More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).  Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system

NOTE: Annals volumes are available for sale as individual books or as a journal Medical books Barriers And Channels Formed By Tight Junction Proteins Ii Fromm, Michael. format paperback language english publication year 17 08 2012 series annals of the new york academy of sciences subject mathematics sciences subject 2 chemistry title barriers and channels formed by tight junction proteins ii author fromm michael publisher blackwell pub publication date jul 24 2012 pages unknown binding paperback edition 1 st dimensions 6 75 wx 9 75 hx 0 25 d isbn 1573318922 subject science life sciences cytology brand new paperback all orders get full access to our online sta

Download link for Barriers And Channels Formed By Tight Junction Proteins I By Paperback Book

format paperback language english publication year 17 08 2012 series annals of the new york academy of sciences subject mathematics sciences subject 2 chemistry title barriers and channels formed by tight junction proteins ii author fromm michael publisher blackwell pub publication date jul 24 2012 pages unknown binding paperback edition 1 st dimensions 6 75 wx 9 75 hx 0 25 d isbn 1573318922 subject science life sciences cytology brand new paperback all orders get full access to our online sta

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically,

Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) an

Contributors: Michael Fromm - Editor. Format: Paperback

Medical Book Barriers and Channels Formed by Tight Junction Proteins I

More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).  Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system

NOTE: Annals volumes are available for sale as individual books or as a journal. For informatio.n on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

 

Barriers and Channels Formed by Tight Junction Proteins II

Author:
Edition: 1
Publisher: Wiley-Blackwell
Binding: Paperback
ISBN: 1573318922

Barriers and Channels Formed by Tight Junction Proteins II (Annals of the New York Academy of Sciences)

Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Medical books Barriers and Channels Formed by Tight Junction Proteins II .

Biological Membrane Ion Channels

Author:
Edition: 2007
Publisher: Springer
Binding: Hardcover
ISBN: 0387333231

Biological Membrane Ion Channels: Dynamics, Structure, and Applications (Biological and Medical Physics, Biomedical Engineering)

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. Medical books Biological Membrane Ion Channels. Medical books Biological Membrane Ion Channels: Dynamics, Structure, And Applications. Electronics Cameras Computers Software Housewares Sports DVDs Music Books Games Toys in titles descriptions Company Info |Checkout Info |Shipping Info |Return Policy |FAQ's Add us as a favorite seller By continuing with your purchase using the eBay Buy It Now button, you agree to the Buy Terms of Use at http://stores.ebay.com/Buys-Internet-Superstore/Terms.html . Biological Membrane Ion Channels: Dynamics, Structure, and Applications THIS IS A BRAND NEW UNOPENED ITEM. Buy SKU: 240880518 If you

Download link for Biological Membrane Ion Channels. Dynamics, Structure and Applns

Electronics Cameras Computers Software Housewares Sports DVDs Music Books Games Toys in titles descriptions Company Info |Checkout Info |Shipping Info |Return Policy |FAQ's Add us as a favorite seller By continuing with your purchase using the eBay Buy It Now button, you agree to the Buy Terms of Use at http://stores.ebay.com/Buys-Internet-Superstore/Terms.html . Biological Membrane Ion Channels: Dynamics, Structure, and Applications THIS IS A BRAND NEW UNOPENED ITEM. Buy SKU: 240880518 If you

Store Search search Title, ISBN and Author Biological Membrane Ion Channels Estimated delivery 3-12 business days Format Paperback Condition Brand New This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevi

Biological Membrane Ion Channels Dynamics, Structure, And Applications, ISBN-13: 9780387333236, ISBN-10: 0387333231

Biological Membrane Ion Channels: Dynamics, Structure, and Applications Springer 9781441922076 09781441922076

Medical Book Biological Membrane Ion Channels

With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.