Author:
Edition: 1
Publisher: Wiley
Binding: Hardcover
ISBN: 0470041382
Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena
A consolidated and comprehensive reference on ligand-binding assaysLigand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Medical books Ligand-Binding Assays. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field.
Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include:
A general discussion of challenges and proven approaches in the development of ligand-binding assays
More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline
A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules
A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies
Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry Medical books Ligand-Binding Assays: Development, Validation, and Implementation in. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena by Khan, Masood N./ Findlay, John W. [Hardcover]
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Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena by Khan, Masood N./ Findlay, John W. [Hardcover]
Store Search search Title, ISBN and Author Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena by Masood N. Khan Estimated delivery 3-12 business days Format Hardcover Condition Brand New With increasing use of ligand-binding assays (LBAs) in the pharmaceutical industry, the need to critically evaluate technical and regulatory issues related to the use of these technologies has increased greatly. Publisher Description With increasing use of ligand-bi
Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena, ISBN-13: 9780470041383, ISBN-10: 0470041382
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics ofPreface. Contributors. 1 Ligand-Binding Assays in Drug Development: Introduction and Historical Perspective (John WA Findlay and Masood N. Khan). 1.1 General. 1.2 Historical Review. 1.3 LBAs for Ma
Medical Book Ligand-Binding Assays
Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development.
Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field.
Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include:
A general discussion of challenges and proven approaches in the development of ligand-binding assays
More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline
A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules
A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies
Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
